Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer (2024)

腹水卵巢癌转移癌症研究生物 CD8型癌症原发性肿瘤肿瘤进展病理医学免疫学免疫系统内科学

作者

Xiaodong Zheng,Xinjing Wang,Xueqing Cheng,Zhaoyuan Liu,Yujia Yin,Xiaoduan Li,Zhihao Huang,Ziliang Wang,Wenping Guo,Florent Ginhoux,Ziyi Li,Zemin Zhang,Xipeng Wang

出处

期刊：Nature cancer [Springer Nature]
日期：2023-07-24 卷期号：4 (8): 1138-1156 被引量：9

链接

nature.com nih.gov nih.govdoi.org

标识

DOI：10.1038/s43018-023-00599-8

摘要

Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC ecosystem with five tumor-relevant sites, including omentum metastasis and malignant ascites. Our data reveal the potential roles of ascites-enriched memory T cells as a pool for tumor-infiltrating exhausted CD8+ T cells and T helper 1-like cells. Moreover, tumor-enriched macrophages exhibited a preference for monocyte-derived ontogeny, whereas macrophages in ascites were more of embryonic origin. Furthermore, we characterized MAIT and dendritic cells in malignant ascites, as well as two endothelial subsets in primary tumors as predictive biomarkers for platinum-based chemotherapy response. Taken together, our study provides a global view of the female malignant ascites ecosystem and offers valuable insights for its connection with tumor tissues and paves the way for potential markers of efficacy evaluation and therapy resistance in OC.

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